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Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Xi-Cheng Zhang
  • Vol. 39, Iss. 9 — May. 1, 2014
  • pp: 2599–2602

Laser-induced cavitation in nanoemulsion with gold nanospheres for blood clot disruption: in vitro results

Chen-wei Wei, Jinjun Xia, Michael Lombardo, Camilo Perez, Bastien Arnal, Kjersta Larson-Smith, Ivan Pelivanov, Thomas Matula, Lilo Pozzo, and Matthew O’Donnell  »View Author Affiliations


Optics Letters, Vol. 39, Issue 9, pp. 2599-2602 (2014)
http://dx.doi.org/10.1364/OL.39.002599


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Abstract

Optically activated cavitation in a nanoemulsion contrast agent is proposed for therapeutic applications. With a 56°C boiling point perfluorohexane core and highly absorptive gold nanospheres at the oil–water interface, cavitation nuclei in the core can be efficiently induced with a laser fluence below medical safety limits (70mJ/cm2 at 1064 nm). This agent is also sensitive to ultrasound (US) exposure and can induce inertial cavitation at a pressure within the medical diagnostic range. Images from a high-speed camera demonstrate bubble formation in these nanoemulsions. The potential of using this contrast agent for blood clot disruption is demonstrated in an in vitro study. The possibility of simultaneous laser and US excitation to reduce the cavitation threshold for therapeutic applications is also discussed.

© 2014 Optical Society of America

OCIS Codes
(000.1430) General : Biology and medicine
(110.7170) Imaging systems : Ultrasound
(170.1610) Medical optics and biotechnology : Clinical applications
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.7170) Medical optics and biotechnology : Ultrasound
(160.4236) Materials : Nanomaterials

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: December 11, 2013
Revised Manuscript: March 1, 2014
Manuscript Accepted: March 22, 2014
Published: April 21, 2014

Virtual Issues
Vol. 9, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Chen-wei Wei, Jinjun Xia, Michael Lombardo, Camilo Perez, Bastien Arnal, Kjersta Larson-Smith, Ivan Pelivanov, Thomas Matula, Lilo Pozzo, and Matthew O’Donnell, "Laser-induced cavitation in nanoemulsion with gold nanospheres for blood clot disruption: in vitro results," Opt. Lett. 39, 2599-2602 (2014)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-39-9-2599


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