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Optics Letters

Optics Letters


  • Vol. 11, Iss. 3 — Mar. 1, 1986
  • pp: 150–152

Femtosecond optical ranging in biological systems

J. G. Fujimoto, S. De Silvestri, E. P. Ippen, C. A. Puliafito, R. Margolis, and A. Oseroff  »View Author Affiliations

Optics Letters, Vol. 11, Issue 3, pp. 150-152 (1986)

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Optical ranging using femtosecond laser pulses and nonlinear-optical cross correlation is demonstrated for the investigation of the microstructure of biological systems. By using pulses of 65-fsec duration generated by a colliding-pulse mode-locked ring dye laser, a spatial resolution of less than 15 μm is achieved with a detection sensitivity to remitted signals as small as 10−7 of the incident pulse energy. This technique is applied to measure the cornea in rabbit eyes in vivo as well as to investigate the epidermal structure of human skin in vitro.

© 1986 Optical Society of America

Original Manuscript: October 18, 1985
Manuscript Accepted: December 5, 1985
Published: March 1, 1986

J. G. Fujimoto, C. A. Puliafito, R. Margolis, A. Oseroff, S. De Silvestri, and E. P. Ippen, "Femtosecond optical ranging in biological systems," Opt. Lett. 11, 150-152 (1986)

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