OSA's Digital Library

Optics Letters

Optics Letters


  • Vol. 20, Iss. 21 — Nov. 1, 1995
  • pp: 2258–2260

Determination of the refractive index of highly scattering human tissue by optical coherence tomography

G. J. Tearney, M. E. Brezinski, J. F. Southern, B. E. Bouma, M. R. Hee, and J. G. Fujimoto  »View Author Affiliations

Optics Letters, Vol. 20, Issue 21, pp. 2258-2260 (1995)

View Full Text Article

Enhanced HTML    Acrobat PDF (332 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



We describe two new techniques, based on optical coherence tomography (OCT), for determining the refractive index of highly scattering human tissue. We obtained refractive indices of in vitro human tissue, using OCT to measure the physical and optical path lengths of the sample. We obtained measurements of the refractive index of in vitro and in vivo human tissue, using OCT to track the focal length shift that results from translating the focus along the optic axis within the tissue. The refractive indices of human skin, adipose, and muscle were measured and compared with previously published estimates.

© 1995 Optical Society of America

Original Manuscript: July 17, 1995
Published: November 1, 1995

G. J. Tearney, M. E. Brezinski, B. E. Bouma, M. R. Hee, J. F. Southern, and J. G. Fujimoto, "Determination of the refractive index of highly scattering human tissue by optical coherence tomography," Opt. Lett. 20, 2258-2260 (1995)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. F. P. Bolin, L. E. Preuss, R. C. Taylor, R. J. Ference, Appl. Opt. 28, 2297 (1989). [CrossRef] [PubMed]
  2. T. Gahm, S. Witte, J. Microsc. (Oxford) 141, 101 (1986). [CrossRef] [PubMed]
  3. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, Science 254, 1178 (1991). [CrossRef] [PubMed]
  4. J. M. Schmitt, A. Knuttel, M. Yadlowsky, M. A. Eckhaus, Phys. Med. Biol. 39, 1705 (1994). [CrossRef] [PubMed]
  5. G. M. Hale, M. R. Querry, Appl. Opt. 12, 555 (1973). [CrossRef] [PubMed]
  6. M. Bass, ed., Handbook of Optics, 2nd ed. (Optical Society of America, Washington, D.C., 1995), Vol. 1, p. 43.21.
  7. M. J. C. Van Gemert, S. L. Jaques, H. J. C. M. Sterenborg, W. M. Star, IEEE Trans. Biomed. Eng. 36, 1146 (1989). [CrossRef] [PubMed]
  8. R. R. Anderson, J. A. Parrish, J. Invest. Dermatol. 77, 13 (1981). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


Fig. 1 Fig. 2 Fig. 3

« Previous Article

OSA is a member of CrossRef.

CrossCheck Deposited