Fluorescence lifetime imaging in turbid media
Optics Letters, Vol. 21, Issue 2, pp. 158-160 (1996)
http://dx.doi.org/10.1364/OL.21.000158
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Abstract
The lifetime of a f luorophore generally varies in different environments, making the molecule a sensitive indicator of tissue oxygenation, pH, and glucose. However, lifetime measurements are complicated when the f luorophore is embedded in an optically thick, highly scattering medium such as human tissue. We formulate the inverse problem for f luorescence lifetime tomography using diffuse photon density waves, and we demonstrate the technique by deriving spatial images of heterogeneous f luorophore distribution and lifetime, using simulated measurements in heterogeneous turbid media.
© 1996 Optical Society of America
Citation
M. A. O’Leary, D. A. Boas, X. D. Li, B. Chance, and A. G. Yodh, "Fluorescence lifetime imaging in turbid media," Opt. Lett. 21, 158-160 (1996)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-21-2-158
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