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Optics Letters

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  • Vol. 23, Iss. 7 — Apr. 1, 1998
  • pp: 555–557

Separation of changes in light scattering and chromophore concentrations during cortical spreading depression in rats

Matthias Kohl, Ute Lindauer, Ulrich Dirnagl, and Arno Villringer  »View Author Affiliations


Optics Letters, Vol. 23, Issue 7, pp. 555-557 (1998)
http://dx.doi.org/10.1364/OL.23.000555


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Abstract

We used near-infrared spectroscopy to separate tissue scattering changes from changes in cerebral oxyhemoglobin and deoxyhemoglobin and the redox state of cytochrome- c -oxidase. A separate term of the transport scattering coefficient (µs) was included in a modified Lambert–Beer equation. It is shown by diffusion equation analysis that there is a simple relationship between the differential path-length factor (Da) and its scattering equivalent (Ds) . The method was applied to cortical spreading depression (CSD) data recorded through the skulls of rats. Biphasic changes in µsof ±0.1mm-1were observed during CSD’s that spread with a velocity of ~5mm/min . The method proposed has the promise to permit monitoring of scattering changes noninvasively in humans during cortical activation or pathophysiological conditions.

© 1998 Optical Society of America

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.5280) Medical optics and biotechnology : Photon migration
(170.6930) Medical optics and biotechnology : Tissue

Citation
Matthias Kohl, Ute Lindauer, Ulrich Dirnagl, and Arno Villringer, "Separation of changes in light scattering and chromophore concentrations during cortical spreading depression in rats," Opt. Lett. 23, 555-557 (1998)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-23-7-555


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