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Optics Letters

Optics Letters


  • Vol. 23, Iss. 8 — Apr. 15, 1998
  • pp: 648–650

Three-dimensional photoacoustic imaging of blood vessels in tissue

C. G. A. Hoelen, F. F. M. de Mul, R. Pongers, and A. Dekker  »View Author Affiliations

Optics Letters, Vol. 23, Issue 8, pp. 648-650 (1998)

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We applied photoacoustics as a tissue tomography technique for the detection of blood concentrations, e.g., angiogenesis around tumors. We imaged blood vessels in highly scattering samples, using 532-nm light, to depths of ~1 cm . The samples were real tissue (chicken breast) or 10% dilutions of Intralipid-10%. The blood flowed through nylon capillaries. Polyvinylidene difluoride (PVdF) piezoelectric detectors were used in a surface-scanning mode. We demonstrate the sensitivity of the technique by photoacoustic detection of single red blood cells upon a glass plate. Lateral resolution is limited by the detector diameter (200 µm). The depth resolution is ~10 µm.

© 1998 of America

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.1870) Medical optics and biotechnology : Dermatology
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.6930) Medical optics and biotechnology : Tissue

C. G. A. Hoelen, F. F. M. de Mul, R. Pongers, and A. Dekker, "Three-dimensional photoacoustic imaging of blood vessels in tissue," Opt. Lett. 23, 648-650 (1998)

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