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Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Vol. 24, Iss. 17 — Sep. 1, 1999
  • pp: 1221–1223

In vivo ultrahigh-resolution optical coherence tomography

W. Drexler, U. Morgner, F. X. Kärtner, C. Pitris, S. A. Boppart, X. D. Li, E. P. Ippen, and J. G. Fujimoto  »View Author Affiliations


Optics Letters, Vol. 24, Issue 17, pp. 1221-1223 (1999)
http://dx.doi.org/10.1364/OL.24.001221


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Abstract

Ultrahigh-resolution optical coherence tomography (OCT) by use of state of the art broad-bandwidth femtosecond laser technology is demonstrated and applied to in vivo subcellular imaging. Imaging is performed with a Kerr-lens mode-locked Ti:sapphire laser with double-chirped mirrors that emits sub-two-cycle pulses with bandwidths of up to 350 nm, centered at 800 nm. Longitudinal resolutions of ~1μm and transverse resolution of 3μm, with a 110-dB dynamic range, are achieved in biological tissue. To overcome depth-of-field limitations we perform zone focusing and image fusion to construct a tomogram with high transverse resolution throughout the image depth. To our knowledge this is the highest longitudinal resolution demonstrated to date for in vivo OCT imaging.

© 1999 Optical Society of America

OCIS Codes
(110.6960) Imaging systems : Tomography
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(140.4050) Lasers and laser optics : Mode-locked lasers
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(320.7090) Ultrafast optics : Ultrafast lasers

Citation
W. Drexler, U. Morgner, F. X. Kärtner, C. Pitris, S. A. Boppart, X. D. Li, E. P. Ippen, and J. G. Fujimoto, "In vivo ultrahigh-resolution optical coherence tomography," Opt. Lett. 24, 1221-1223 (1999)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-24-17-1221

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