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Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Vol. 24, Iss. 23 — Dec. 1, 1999
  • pp: 1726–1728

Frequency-domain immersion technique for accurate optical property measurements of turbid media

Martina Gerken and Gregory W. Faris  »View Author Affiliations


Optics Letters, Vol. 24, Issue 23, pp. 1726-1728 (1999)
http://dx.doi.org/10.1364/OL.24.001726


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Abstract

We demonstrate that absorption coefficient µa and reduced scattering coefficient µs of a small turbid object can be measured to high accuracy with a frequency-domain immersion technique. For this technique the sample is immersed in a calibrated scattering medium and the optical properties are obtained from a differential measurement. Compared with conventional approaches, the immersion technique improves accuracy, minimizes variations owing to probe coupling and motion, reduces the effects of boundary conditions, and offers simple and rapid measurement once the immersion medium is calibrated. Accuracy tests of immersion-based measurements of µa and µs agree with reference values to within 3.6% and 2.6%, respectively. These tests are limited by the accuracy of the reference samples rather than by the accuracy of the immersion medium or the precision of the immersion approach. We demonstrate the in vivo capabilities of the technique through time-resolved measurements of µa and µs for a human hand during cuff occlusion on the upper arm.

© 1999 Optical Society of America

OCIS Codes
(170.5270) Medical optics and biotechnology : Photon density waves
(170.5280) Medical optics and biotechnology : Photon migration
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.7050) Medical optics and biotechnology : Turbid media
(290.1990) Scattering : Diffusion
(290.4210) Scattering : Multiple scattering

Citation
Martina Gerken and Gregory W. Faris, "Frequency-domain immersion technique for accurate optical property measurements of turbid media," Opt. Lett. 24, 1726-1728 (1999)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-24-23-1726


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References

  1. J. G. Fujimoto and M. S. Patterson, eds., Advances in Optical Imaging and Photon Migration, Vol. 21 of OSA Trends in Optics and Photonics Series (Optical Society of America, Washington, D.C., 1998).
  2. B. Chance, R. R. Alfano, and B. J. Tromberg, eds., Optical Tomography and Spectroscopy of Tissue III (SPIE, Bellingham, Wash., 1999).
  3. B. Chance, M. Cope, E. Gratton, N. Ramanujam, and B. Tromberg, Rev. Sci. Instrum. 69, 3457 (1998).
  4. M. Gerken and G. W. Faris, Opt. Lett. 24, 930 (1999).
  5. X. Wu, L. Stinger, and G. W. Faris, Proc. SPIE 2979, 300 (1997).
  6. H. Liu, M. Miwa, B. Beauvoit, N. G. Wang, and B. Chance, Anal. Biochem. 213, 378 (1993).
  7. S. Fantini, M. A. Franceschini, J. B. Fishkin, B. Barbieri, and E. Gratton, Appl. Opt. 33, 5204 (1994).
  8. S. A. Walker, D. A. Boas, and E. Gratton, Appl. Opt. 37, 1935 (1998).
  9. R. Aronson, J. Opt. Soc. Am. A 12, 2532 (1995).
  10. C. F. Bohren and D. R. Huffman, Absorption and Scattering of Light by Small Particles (Wiley, New York, 1983), pp. 479–481.
  11. L. A. Matheson and J. L. Saunderson, in Styrene, Its Polymers, Copolymers, and Derivatives, R. H. Boundy and R. F. Boyer, eds. (Reinhold, New York, 1952), pp. 517–573.
  12. V. V. Tuchin, S. R. Utz, and I. V. Yaroslavsky, in Medical Optical Tomography: Functional Imaging and Monitoring, G. Müller, B. Chance, R. Alfano, S. Arridge, J. Beuthan, E. Gratton, M. Kaschke, B. Masters, S. Svanberg, and P. Van der Zee, eds. (SPIE, Bellingham, Wash., 1993), pp. 234–258.
  13. S. J. Matcher, C. E. Elwell, C. E. Cooper, M. Cope, and D. T. Delpy, Anal. Biochem. 227, 54 (1995).
  14. R. A. DeBlasi, M. Ferrari, A. Natali, G. Conti, A. Mega, and A. Gasparetto, J. Appl. Physiol. 76, 1388 (1994).
  15. A. T. Lovell, J. C. Hebden, J. C. Goldstone, and M. Cope, Proc. SPIE 3597, 175 (1999).
  16. X. Wu and G. W. Faris, Appl. Opt. 38, 4262 (1999).

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