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Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Vol. 25, Iss. 18 — Sep. 15, 2000
  • pp: 1358–1360

Doppler standard deviation imaging for clinical monitoring of in vivo human skin blood flow

Yonghua Zhao, Zhongping Chen, Christopher Saxer, Qimin Shen, Shaohua Xiang, Johannes F. de Boer, and J. Stuart Nelson  »View Author Affiliations


Optics Letters, Vol. 25, Issue 18, pp. 1358-1360 (2000)
http://dx.doi.org/10.1364/OL.25.001358


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Abstract

We used a novel phase-resolved optical Doppler tomographic (ODT) technique with very high flow-velocity sensitivity (10µm/s) and high spatial resolution (10µm) to image blood flow in port-wine stain (PWS) birthmarks in human skin. In addition to the regular ODT velocity and structural images, we use the variance of blood flow velocity to map the PWS vessels. Our device combines ODT and therapeutic systems such that PWS blood flow can be monitored in situ before and after laser treatment. To the authors' knowledge this is the first clinical application of ODT to provide a fast semiquantitative evaluation of the efficacy of PWS laser therapy in situ and in real time.

© 2000 Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.4500) Medical optics and biotechnology : Optical coherence tomography

Citation
Yonghua Zhao, Zhongping Chen, Christopher Saxer, Qimin Shen, Shaohua Xiang, Johannes F. de Boer, and J. Stuart Nelson, "Doppler standard deviation imaging for clinical monitoring of in vivo human skin blood flow," Opt. Lett. 25, 1358-1360 (2000)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-25-18-1358


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References

  1. Z. Chen, Y. Zhao, S. M. Srinivas, J. S. Nelson, N. Prakash, and R. D. Frostig, IEEE J. Sel. Top. Quantum Electron. 5, 1134 (1999).
  2. M. D. Kulkarni, T. G. van Leeuwen, S. Yazdanfar, and J. A. Izatt, Opt. Lett. 23, 1057 (1998).
  3. Z. Chen, T. E. Milner, D. Dave, and J. S. Nelson, Opt. Lett. 22, 64 (1997).
  4. Y. Zhao, Z. Chen, C. Saxer, S. Xiang, J. F. de Boer, and J. S. Nelson, Opt. Lett. 25, 114 (2000).
  5. S. H. Barsky, S. Rosen, D. E. Greer, and J. M. Noe, J. Invest. Dermatol. 74, 154 (1980).
  6. J. S. Nelson, Plast. Reconstr. Surg. 88, 723 (1991).
  7. G. J. Tearney, B. E. Bouma, and J. G. Fujimoto, Opt. Lett. 22, 1811 (1997).

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