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Optics Letters

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  • Vol. 25, Iss. 19 — Oct. 1, 2000
  • pp: 1451–1453

Turbidity-free fluorescence spectroscopy of biological tissue

Qingguo Zhang, Markus G. Müller, Jun Wu, and Michael S. Feld  »View Author Affiliations


Optics Letters, Vol. 25, Issue 19, pp. 1451-1453 (2000)
http://dx.doi.org/10.1364/OL.25.001451


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Abstract

We present a method based on photon migration of extracting intrinsic fluorescence spectra from turbid media, using concomitantly measured fluorescence and reflectance. Intrinsic fluorescence is defined as fluorescence that is due only to fluorophores, without interference from the absorbers and scatterers that are present. Application to fluorescence spectra taken with tissue phantoms and human mucosal tissues demonstrates excellent agreement in both spectral line shape and intensity between the extracted and the directly measured intrinsic fluorescence spectra.

© 2000 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.7050) Medical optics and biotechnology : Turbid media

Citation
Qingguo Zhang, Markus G. Müller, Jun Wu, and Michael S. Feld, "Turbidity-free fluorescence spectroscopy of biological tissue," Opt. Lett. 25, 1451-1453 (2000)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-25-19-1451


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