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Optics Letters

Optics Letters


  • Vol. 26, Iss. 11 — Jun. 1, 2001
  • pp: 825–827

Time-gated biological imaging by use of colloidal quantum dots

M. Dahan, T. Laurence, F. Pinaud, D. S. Chemla, A. P. Alivisatos, M. Sauer, and S. Weiss  »View Author Affiliations

Optics Letters, Vol. 26, Issue 11, pp. 825-827 (2001)

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The long (but not too long) fluorescence lifetime of CdSe semiconductor quantum dots was exploited to enhance fluorescence biological imaging contrast and sensitivity by time-gated detection. Significant and selective reduction of the autofluorescence contribution to the overall image was achieved, and enhancement of the signal-to-background ratio by more than an order of magnitude was demonstrated.

© 2001 Optical Society of America

OCIS Codes
(170.1790) Medical optics and biotechnology : Confocal microscopy
(170.2520) Medical optics and biotechnology : Fluorescence microscopy
(170.3650) Medical optics and biotechnology : Lifetime-based sensing
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6920) Medical optics and biotechnology : Time-resolved imaging

M. Dahan, T. Laurence, F. Pinaud, D. S. Chemla, A. P. Alivisatos, M. Sauer, and S. Weiss, "Time-gated biological imaging by use of colloidal quantum dots," Opt. Lett. 26, 825-827 (2001)

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