Time-gated biological imaging by use of colloidal quantum dots
Optics Letters, Vol. 26, Issue 11, pp. 825-827 (2001)
http://dx.doi.org/10.1364/OL.26.000825
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Abstract
The long (but not too long) fluorescence lifetime of CdSe semiconductor quantum dots was exploited to enhance fluorescence biological imaging contrast and sensitivity by time-gated detection. Significant and selective reduction of the autofluorescence contribution to the overall image was achieved, and enhancement of the signal-to-background ratio by more than an order of magnitude was demonstrated.
© 2001 Optical Society of America
[Optical Society of America ]
OCIS Codes
(170.1790) Medical optics and biotechnology : Confocal microscopy
(170.2520) Medical optics and biotechnology : Fluorescence microscopy
(170.3650) Medical optics and biotechnology : Lifetime-based sensing
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6920) Medical optics and biotechnology : Time-resolved imaging
Citation
M. Dahan, T. Laurence, F. Pinaud, D. S. Chemla, A. P. Alivisatos, M. Sauer, and S. Weiss, "Time-gated biological imaging by use of colloidal quantum dots," Opt. Lett. 26, 825-827 (2001)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-26-11-825
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