OSA's Digital Library

Optics Letters

Optics Letters


  • Vol. 26, Iss. 16 — Aug. 15, 2001
  • pp: 1268–1270

Optical processing of light-induced autofluorescence for characterization of tissue pathology

Jianan Qu, Hanpeng Chang, and Shengming Xiong  »View Author Affiliations

Optics Letters, Vol. 26, Issue 16, pp. 1268-1270 (2001)

View Full Text Article

Acrobat PDF (83 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



We describe an optical processing method for characterizing tissue pathology that is based on principal-component analysis of light-induced autofluorescence. A set of optical spectral filters, which are related to the principal-component loading vectors, is designed to process the autofluorescence signal optically and to generate principal-component scores from the autofluorescence spectra. The scores are then correlated with the tissue pathology. An optical processing system is designed that uses the in vivo fluorescence spectra recorded from nasopharyngeal tissues. We demonstrate that the system can differentiate nasopharyngeal carcinoma from normal tissue with a high degree of sensitivity and specificity and that the optical filters used in the system can be manufactured.

© 2001 Optical Society of America

OCIS Codes
(110.7050) Imaging systems : Turbid media
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

Jianan Qu, Hanpeng Chang, and Shengming Xiong, "Optical processing of light-induced autofluorescence for characterization of tissue pathology," Opt. Lett. 26, 1268-1270 (2001)

Sort:  Author  |  Year  |  Journal  |  Reset


  1. K. M. O'Brien, A. F. Gmitro, G. R. Gindi, M. L. Stetz, F. W. Gutruzzola, L. I. Laifer, and L. I. Deckelbaum, IEEE Trans. Biomed. Eng. 36, 424 (1989).
  2. N. Ramanujam, M. F. Mitchell, A. Mahadevan, S. Thomsen, A. Malpica, T. Wright, N. Atkinson, and R. Richards-Kortum, Lasers Surg. Med. 19, 46 (1996).
  3. Z. Ge, C. W. Brown, and H. J. Kisner, Appl. Spectrosc. 49, 432 (1995).
  4. G. Deinum, D. Rodriguez, T. J. Romer, M. Fitzmaurice, J. R. Kramer, and M. S. Feld, Appl. Spectrosc. 53, 938 (1999).
  5. C. A. Drumm and M. D. Morris, Appl. Spectrosc. 49, 1331 (1995).
  6. J. Y. Qu, W. P. Yuen, Z. J. Huang, D. R. Kwong, J. Sham, S. L. Lee, W. K. Ho, and W. I. Wei, Lasers Surg. Med. 26, 432 (2000).
  7. S. Andersson-Engels, J. Johansson, and S. Svanberg, Appl. Opt. 33, 8022 (1994).

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited