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Optics Letters

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  • Vol. 26, Iss. 17 — Sep. 1, 2001
  • pp: 1335–1337

Perturbation Monte Carlo methods to solve inverse photon migration problems in heterogeneous tissues

Carole K. Hayakawa, Jerome Spanier, Frédéric Bevilacqua, Andrew K. Dunn, Joon S. You, Bruce J. Tromberg, and Vasan Venugopalan  »View Author Affiliations


Optics Letters, Vol. 26, Issue 17, pp. 1335-1337 (2001)
http://dx.doi.org/10.1364/OL.26.001335


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Abstract

We introduce a novel and efficient method to provide solutions to inverse photon migration problems in heterogeneous turbid media. The method extracts derivative information from a single Monte Carlo simulation to permit the rapid determination of rates of change in the detected photon signal with respect to perturbations in background tissue optical properties. We then feed this derivative information to a nonlinear optimization algorithm to determine the optical properties of the tissue heterogeneity under examination. We demonstrate the use of this approach to solve rapidly a two-region inverse problem of photon migration in the transport regime, for which diffusion-approximation-based approaches are not applicable.

© 2001 Optical Society of America

OCIS Codes
(100.3190) Image processing : Inverse problems
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.5280) Medical optics and biotechnology : Photon migration
(170.7050) Medical optics and biotechnology : Turbid media

Citation
Carole K. Hayakawa, Jerome Spanier, Frédéric Bevilacqua, Andrew K. Dunn, Joon S. You, Bruce J. Tromberg, and Vasan Venugopalan, "Perturbation Monte Carlo methods to solve inverse photon migration problems in heterogeneous tissues," Opt. Lett. 26, 1335-1337 (2001)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-26-17-1335


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References

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