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Optics Letters

Optics Letters


  • Vol. 26, Iss. 22 — Nov. 15, 2001
  • pp: 1782–1784

Rapid near-infrared Raman spectroscopy system for real-time in vivo skin measurements

Zhiwei Huang, Haishan Zeng, Iltefat Hamzavi, David I. McLean, and Harvey Lui  »View Author Affiliations

Optics Letters, Vol. 26, Issue 22, pp. 1782-1784 (2001)

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A rapid dispersive-type near-infrared (NIR) Raman spectroscopy system and a Raman probe were developed to facilitate real-time, noninvasive, in vivo human skin measurements. Spectrograph image aberration was corrected by a parabolic-line fiber array, permitting complete CCD vertical binning, thereby yielding a 3.3–16-fold improvement in signal-to-noise ratio. Good quality in vivo cutaneous NIR Raman spectra free of interference from fiber fluorescence and silica Raman scattering can be acquired in less than 1 s, which greatly facilitates practical noninvasive tissue characterization and clinical diagnosis.

© 2001 Optical Society of America

OCIS Codes
(170.1870) Medical optics and biotechnology : Dermatology
(170.5660) Medical optics and biotechnology : Raman spectroscopy
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

Zhiwei Huang, Haishan Zeng, Iltefat Hamzavi, David I. McLean, and Harvey Lui, "Rapid near-infrared Raman spectroscopy system for real-time in vivo skin measurements," Opt. Lett. 26, 1782-1784 (2001)

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