A rapid dispersive-type near-infrared (NIR) Raman spectroscopy system and a Raman probe were developed to facilitate real-time, noninvasive, <i>in vivo</i> human skin measurements. Spectrograph image aberration was corrected by a parabolic-line fiber array, permitting complete CCD vertical binning, thereby yielding a 3.3–16-fold improvement in signal-to-noise ratio. Good quality <i>in vivo</i> cutaneous NIR Raman spectra free of interference from fiber fluorescence and silica Raman scattering can be acquired in less than 1 s, which greatly facilitates practical noninvasive tissue characterization and clinical diagnosis.
© 2001 Optical Society of America
(170.1870) Medical optics and biotechnology : Dermatology
(170.5660) Medical optics and biotechnology : Raman spectroscopy
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
Zhiwei Huang, Haishan Zeng, Iltefat Hamzavi, David I. McLean, and Harvey Lui, "Rapid near-infrared Raman spectroscopy system for real-time in vivo skin measurements," Opt. Lett. 26, 1782-1784 (2001)