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Optics Letters

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  • Vol. 26, Iss. 22 — Nov. 15, 2001
  • pp: 1782–1784

Rapid near-infrared Raman spectroscopy system for real-time in vivo skin measurements

Zhiwei Huang, Haishan Zeng, Iltefat Hamzavi, David I. McLean, and Harvey Lui  »View Author Affiliations


Optics Letters, Vol. 26, Issue 22, pp. 1782-1784 (2001)
http://dx.doi.org/10.1364/OL.26.001782


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Abstract

A rapid dispersive-type near-infrared (NIR) Raman spectroscopy system and a Raman probe were developed to facilitate real-time, noninvasive, in vivo human skin measurements. Spectrograph image aberration was corrected by a parabolic-line fiber array, permitting complete CCD vertical binning, thereby yielding a 3.3–16-fold improvement in signal-to-noise ratio. Good quality in vivo cutaneous NIR Raman spectra free of interference from fiber fluorescence and silica Raman scattering can be acquired in less than 1 s, which greatly facilitates practical noninvasive tissue characterization and clinical diagnosis.

© 2001 Optical Society of America

OCIS Codes
(170.1870) Medical optics and biotechnology : Dermatology
(170.5660) Medical optics and biotechnology : Raman spectroscopy
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

Citation
Zhiwei Huang, Haishan Zeng, Iltefat Hamzavi, David I. McLean, and Harvey Lui, "Rapid near-infrared Raman spectroscopy system for real-time in vivo skin measurements," Opt. Lett. 26, 1782-1784 (2001)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-26-22-1782


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References

  1. A. Mahadevan-Jansen and R. Richards-Kortum, J. Biomed. Opt. 1, 31 (1996).
  2. B. W. Barry, H. G. M. Edwards, and A. C. Williams, J. Raman Spectrosc. 23, 641 (1992).
  3. H. G. M. Edwards, A. C. Williams, and B. W. Barry, J. Mol. Struct. 347, 379 (1995).
  4. M. G. Shim, L. K. Song, N. E. Marcon, and B. C. Wilson, Photochem. Photobiol. 72, 146 (2000).
  5. J. J. Baraga, M. S. Feld, and R. P. Rava, Appl. Spectrosc. 46, 187 (1992).
  6. A. Mahadevan-Jansen, M. F. Mitchell, N. Ramanujam, U. Utzinger, and R. Richards-Kortum, Photochem. Photobiol. 68, 427 (1998).
  7. H. Owen, D. E. Battey, M. J. Pelletier, and J. B. Slater, Proc. SPIE 2406, 260 (1995).
  8. HoloSpec VPT System Operations Manual, Kaiser Optical Systems, Ann Arbor, Mich., 1994.
  9. ST-133 Controller Operations Manual, Princeton Scientific Istruments, Monmouth Junction, N.J., 1997.
  10. A. Mahadevan, N. Ramanujam, M. F. Mitchell, A. Malpica, S. Thomsen, and R. Richards-Kortum, Proc. SPIE 2388, 110 (1995).
  11. H. Zeng, “Apparatus and methods relating to high speed Raman spectroscopy,” U.S. patent pending.
  12. “American National Standard for the Safe Use of Lasers,” ANSI Standard 2136.1–1986 (American National Standards Institute, Washington, D.C., 1986).
  13. P. J. Caspers, G. W. Lucassen, R. Wolthuis, H. A. Bruining, and G. J. Puppels, Biospectroscopy 4, S31 (1998).

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