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Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Vol. 27, Iss. 18 — Sep. 15, 2002
  • pp: 1610–1612

Invivo depth-resolved birefringence measurements of the human retinal nerve fiber layer by polarization-sensitive optical coherence tomography

Barry Cense, Teresa C. Chen, B. Hyle Park, Mark C. Pierce, and Johannes F. de Boer  »View Author Affiliations


Optics Letters, Vol. 27, Issue 18, pp. 1610-1612 (2002)
http://dx.doi.org/10.1364/OL.27.001610


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Abstract

To our knowledge, this is the first demonstration of in vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer (RNFL) by use of polarization-sensitive optical coherence tomography (PS-OCT). Because glaucoma causes nerve fiber layer damage, which may cause loss of retinal birefringence, PS-OCT is a potentially useful technique for the early detection of glaucoma. We built a fiber-based PS-OCT setup that produces quasi-real-time images of the human retina in vivo . Preliminary measurements of a healthy volunteer showed that the double-pass phase retardation per unit depth of the RNFL near the optic nerve head is 39±6°/100µm .

© 2002 Optical Society of America

OCIS Codes
(110.7050) Imaging systems : Turbid media
(170.4460) Medical optics and biotechnology : Ophthalmic optics and devices
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(260.1440) Physical optics : Birefringence

Citation
Barry Cense, Teresa C. Chen, B. Hyle Park, Mark C. Pierce, and Johannes F. de Boer, "Invivo depth-resolved birefringence measurements of the human retinal nerve fiber layer by polarization-sensitive optical coherence tomography," Opt. Lett. 27, 1610-1612 (2002)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-27-18-1610


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