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Optics Letters

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  • Vol. 27, Iss. 20 — Oct. 15, 2002
  • pp: 1794–1796

Gradient-index fiber-optic microprobes for minimally invasive in vivo low-coherence interferometry

William A. Reed, Man F. Yan, and Mark J. Schnitzer  »View Author Affiliations


Optics Letters, Vol. 27, Issue 20, pp. 1794-1796 (2002)
http://dx.doi.org/10.1364/OL.27.001794


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Abstract

We describe the design, construction, and application of what are believed to be the smallest fiber-optic probes used to date during imaging or diagnosis involving low-coherence interferometry (LCI). The probes use novel fiber-optic gradient-index (GRIN) lenses fabricated by a recently developed modified chemical-vapor-deposition (MCVD) process that avoids on-axis aberrations commonly marring MCVD-fabricated GRIN substrate. Fusing GRIN fiber lenses onto single-mode fiber yields automatically aligned all-fiber probes that insert into tissue through hypodermic needles as small as 31-gauge (inner diameter, 127 μm). We demonstrate the use of such probes with LCI by measuring microscopic brain motions <i>in vivo</i>.

© 2002 Optical Society of America

OCIS Codes
(060.2370) Fiber optics and optical communications : Fiber optics sensors
(170.3340) Medical optics and biotechnology : Laser Doppler velocimetry
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine

Citation
William A. Reed, Man F. Yan, and Mark J. Schnitzer, "Gradient-index fiber-optic microprobes for minimally invasive in vivo low-coherence interferometry," Opt. Lett. 27, 1794-1796 (2002)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-27-20-1794


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References

  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
  2. Y. Zhao, Z. Chen, Z. Ding, H. Ren, and J. S. Nelson, Opt. Lett. 27, 98 (2002).
  3. V. Westphal, S. Yazdanfar, A. M. Rollins, and J. A. Izatt, Opt. Lett. 27, 34 (2002).
  4. B. H. Park, C. Saxer, S. M. Srinivas, J. S. Nelson, and J. de Boer, J. Biomed. Opt. 6, (2001).
  5. W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, S. Schuman, and J. G. Fujimoto, Nat. Med. (N.Y.) 7, 502 (2001).
  6. G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, Science 276, 2037 (1997).
  7. X. Li, C. Chudoba, C. Ko, C. Pritris, and J. Fujimoto, Opt. Lett. 25, 1520 (2000).
  8. B. Messerschmidt, U. Possner, and S. N. Houde-Walter, Appl. Opt. 36, 8145 (1997).
  9. J. B. MacChesney, Proc. IEEE 68, 1181 (1980).
  10. W. L. Emkey and C. A. Jack, J. Lightwave Technol. 5, 1156 (1987).
  11. J. C. Rousseau and R. Sauvageon, “Method of controlling the etching and collapse of an MCVD tube by monitoring internal pressure,” U.S. patent 6, 131, 413 (October 17, 2000).
  12. M. S. Fee, Neuron 27, 461 (2000).

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