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Optics Letters

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  • Vol. 28, Iss. 12 — Jun. 15, 2003
  • pp: 1019–1021

Fluorescence tomography with simulated data based on the equation of radiative transfer

Alexander D. Klose and AndreasH. Hielscher  »View Author Affiliations


Optics Letters, Vol. 28, Issue 12, pp. 1019-1021 (2003)
http://dx.doi.org/10.1364/OL.28.001019


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Abstract

The quantification of a nonuniform quantum yield or fluorophore absorption distribution is of major interest in molecular imaging of biological tissue. We introduce what is believed to be the first fluorescence image reconstruction algorithm based on the equation of radiative transfer that recovers the spatial distribution of light-emitting fluorophores inside a highly scattering medium from measurements made on the surface of the medium. We obtain images of either the quantum yield or the fluorophore absorption.

© 2003 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5280) Medical optics and biotechnology : Photon migration
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(170.6960) Medical optics and biotechnology : Tomography

Citation
Alexander D. Klose and AndreasH. Hielscher, "Fluorescence tomography with simulated data based on the equation of radiative transfer," Opt. Lett. 28, 1019-1021 (2003)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-28-12-1019


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