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Optics Letters

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  • Vol. 28, Iss. 14 — Jul. 15, 2003
  • pp: 1215–1217

Measurement of dye diffusion in agar gel by use of low-coher ence interferometry

Trude Støren, Annette Simonsen, Ole J. Løkberg, Tore Lindmo, Lars O. Svaasand, and Arne Røyset  »View Author Affiliations


Optics Letters, Vol. 28, Issue 14, pp. 1215-1217 (2003)
http://dx.doi.org/10.1364/OL.28.001215


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Abstract

We demonstrate low-coherence interferometry for diffusion measurements. We have measured the diffusion coefficient of a phthalocyanine dye in 1.5% agar gel with a two-wavelength interferometer; one wavelength was matched to the absorption peak of the dye at 675 nm, while the other, 805 nm, was not affected by the dye. The diffusion coefficient of the dye was found by fitting a mathematical model for the interferometer signal to the measured low-coherence interferometry amplitude. A 95% confidence interval for the diffusion coefficient was found to be D=(2.5±0.2)×10-10m2/s . The influence of speckle averaging and experiment time on the determination of the diffusion coefficient has been studied. The presented technique allows in situ characterization of diffusion in semitransparent media.

© 2003 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.5180) Medical optics and biotechnology : Photodynamic therapy
(300.1030) Spectroscopy : Absorption

Citation
Trude Støren, Annette Simonsen, Ole J. Løkberg, Tore Lindmo, Lars O. Svaasand, and Arne Røyset, "Measurement of dye diffusion in agar gel by use of low-coher ence interferometry," Opt. Lett. 28, 1215-1217 (2003)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-28-14-1215


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References

  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
  2. J. G. Fujimoto, C. Pitris, S. Boppart, and M. Brezinski, Neoplasia 2, 9 (2000).
  3. Z. P. Chen, T. E. Milner, S. Srinivas, X. J. Wang, A. Malekafzali, M. J. C. van Gemert, and J. S. Nelson, Opt. Lett. 22, 1 (1997).
  4. J. F. deBoer, T. E. Milner, M. J. C. van Gemert, and J. S. Nelson, Opt. Lett. 22, 934 (1997).
  5. J. M. Schmitt, S. H. Xiang, and K. M. Yung, J. Opt. Soc. Am. A 15, 2288 (1998).
  6. U. Morgner, W. Drexler, F. X. Kärtner, X. D. Li, C. Pitris, E. P. Ippen, and J. G. Fujimoto, Opt. Lett. 25, 111 (2000).
  7. W. M. Star, Phys. Med. Biol. 42, 763 (1997).
  8. B. A. Westrin, A. Axelsson, and G. Zacchi, J. Controlled Release 30, 189 (1994).
  9. R. A. Weersink, J. E. Hayward, K. R. Diamond, and M. S. Patterson, Photochem. Photobiol. 66, 326 (1997).
  10. J. R. Mourant, T. M. Johnson, G. Los, and I. J. Bigio, Phys. Med. Biol. 44, 1397 (1999).
  11. D. E. Hyde, T. J. Farrel, M. S. Patterson, and B. C. Wilson, Phys. Med. Biol. 46, 369 (2001).
  12. L. O. Svaasand, P. Wyss, M. T. Wyss, Y. Tadir, B. J. Tromberg, and M. W. Berns, Lasers Surg. Med. 18, 139 (1996).
  13. W. M. Star, M. C. G. Aalders, A. Sac, and H. J. C. M. Sterenborg, Photochem. Photobiol. 75, 424 (2002).
  14. P. Gribbon and T. E. Hardingham, Biophys. J. 75, 1032 (1998).
  15. L. Masaro and X. X. Zhu, Prog. Polym. Sci. 24, 731 (1999).
  16. J. Crank, The Mathematics of Diffusion (Oxford U. Press, New York, 1975), pp. 11–16.
  17. T. Støren, A. Simonsen, A. K. Røyset, O. J. Løkberg, L. O. Svaasand, and T. Lindmo, in Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII, V. V. Tuchin, J. A. Izatt, and J. G. Fujimoto, eds., Proc. SPIE 4956 (to be published).
  18. J. R. Lead, K. Starchev, and K. J. Wilkinson, Environ. Sci. Technol. 37, 482 (2003).

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