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Optics Letters

Optics Letters


  • Vol. 28, Iss. 14 — Jul. 15, 2003
  • pp: 1230–1232

Fourier-domain low-coherence interferometry for light-scattering spectroscopy

Adam Wax, Changhuei Yang, and Joseph A. Izatt  »View Author Affiliations

Optics Letters, Vol. 28, Issue 14, pp. 1230-1232 (2003)

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We present a novel method for obtaining depth-resolved spectra for determining scatterer size through elastic-scattering properties. Depth resolution is achieved with a white-light source in a Michelson interferometer with the mixed signal and reference fields dispersed by a spectrograph. The spectrum is Fourier transformed to yield the axial spatial cross correlation between the signal and reference fields with near 1-µm depth resolution. Spectral information is obtained by windowing to yield the scattering amplitude as a function of wave number. The technique is demonstrated by determination of the size of polystyrene microspheres in a subsurface layer with subwavelength accuracy. Application of the technique to probing the size of cell nuclei in living epithelial tissues is discussed.

© 2003 Optical Society of America

OCIS Codes
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(290.1350) Scattering : Backscattering

Adam Wax, Changhuei Yang, and Joseph A. Izatt, "Fourier-domain low-coherence interferometry for light-scattering spectroscopy," Opt. Lett. 28, 1230-1232 (2003)

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  1. V. Backman, V. Gopal, M. Kalashnikov, K. Badizadegan, R. Gurjar, A. Wax, I. Georgakoudi, M. Mueller, C. W. Boone, R. R. Dasari, and M. S. Feld, IEEE J. Sel. Top. Quantum Electron. 7, 887 (2001).
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  4. I. Georgakoudi, E. E. Sheets, M. G. Müller, V. Backman, C. P. Crum, K. Badizadegan, R. R. Dasari, and M. S. Feld, Am. J. Obstet. Gynecol. 186, 374 (2002).
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  6. A. Wax, C. Yang, M. Mueller, R. Nines, C. W. Boone, V. E. Steele, G. D. Stoner, R. R. Dasari, and M. S. Feld, “In situ detection of neoplastic transformation and chemopreventive effects in rat esophagus epithelium using angle-resolved low-coherence interferometry,” Cancer Res (to be published).
  7. C. H. Yang, L. T. Perelman, A. Wax, R. R. Dasari, and M. S. Feld, J. Biomed. Opt. 5, 138 (2000).
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  13. C. Dorrer, N. Belabas, J. P. Likforman, and M. Joffre, J. Opt. Soc. Am. B 17, 1795 (2000).
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