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Optics Letters

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  • Vol. 28, Iss. 15 — Aug. 1, 2003
  • pp: 1329–1331

Optical heterodyne surface-plasmon resonance biosensor

Wen-Chuan Kuo, Chien Chou, and Hsieh-Ting Wu  »View Author Affiliations


Optics Letters, Vol. 28, Issue 15, pp. 1329-1331 (2003)
http://dx.doi.org/10.1364/OL.28.001329


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Abstract

A novel optical heterodyne surface-plasmon resonance (SPR) biosensor with a Zeeman laser is proposed. Two surface plasma waves are excited by two correlated p -polarized waves in a SPR device of the Kretschmann configuration. Two reflected p waves are optically heterodyned such that the magnitude of the heterodyned signal is proportional to the multiplication of two attenuated reflected p waves. Then the detection sensitivity and the dynamic range based on this amplitude-sensitive method are enhanced. In the experiment, the kinetics between mouse immunoglobulin G (IgG) and rabbit antimouse IgG is obtained from sensograms of various concentrations of antimouse IgG. A detection sensitivity of 0.2 nM was achieved. In addition, a concentration of 5 ng/Fml of protein G interacting with mouse IgG was measured successfully.

© 2003 Optical Society of America

OCIS Codes
(240.6680) Optics at surfaces : Surface plasmons
(240.6690) Optics at surfaces : Surface waves

Citation
Wen-Chuan Kuo, Chien Chou, and Hsieh-Ting Wu, "Optical heterodyne surface-plasmon resonance biosensor," Opt. Lett. 28, 1329-1331 (2003)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-28-15-1329


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