OSA's Digital Library

Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Vol. 28, Iss. 17 — Sep. 1, 2003
  • pp: 1546–1548

Engineered microsphere contrast agents for optical coherence tomography

Tin Man Lee, Amy L. Oldenburg, Shoeb Sitafalwalla, Daniel L. Marks, Wei Luo, Farah Jean-Jacques Toublan, Kenneth S. Suslick, and Stephen A. Boppart  »View Author Affiliations


Optics Letters, Vol. 28, Issue 17, pp. 1546-1548 (2003)
http://dx.doi.org/10.1364/OL.28.001546


View Full Text Article

Acrobat PDF (1058 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Contrast agents are utilized in virtually every imaging modality to enhance diagnostic capabilities. We introduce a novel class of optical contrast agent, namely, encapsulating microspheres, that are based not on fluorescence but on scattering nanoparticles within the shell or core. The agents are suitable for reflection- or scattering-based techniques such as optical coherence tomography, light microscopy, and reflectance confocal microscopy. We characterize the optical properties of gold-, melanin-, and carbon-shelled contrast agents and demonstrate enhancement of optical coherence tomography imaging after intravenous injection of such an agent into a mouse.

© 2003 Optical Society of America

OCIS Codes
(160.4760) Materials : Optical properties
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine

Citation
Tin Man Lee, Amy L. Oldenburg, Shoeb Sitafalwalla, Daniel L. Marks, Wei Luo, Farah Jean-Jacques Toublan, Kenneth S. Suslick, and Stephen A. Boppart, "Engineered microsphere contrast agents for optical coherence tomography," Opt. Lett. 28, 1546-1548 (2003)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-28-17-1546

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited