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Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Vol. 28, Iss. 2 — Jan. 15, 2003
  • pp: 120–122

Selective detection of fluorophore layers in turbid media: the role of fiber-optic probe design

T. Joshua Pfefer, L. Stephanie Matchette, Amanda M. Ross, and Marwood N. Ediger  »View Author Affiliations


Optics Letters, Vol. 28, Issue 2, pp. 120-122 (2003)
http://dx.doi.org/10.1364/OL.28.000120


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Abstract

Experimental verification of the ability to alter the sensitivity to fluorophore layers in turbid media by varying illumination-collection geometry is presented. Fiber-optic probes and two-layer, fluorophore-doped, turbid phantoms are used to elucidate the roles of spot size, illumination–collection fiber separation, and probe–sample spacing. Variations in single- and multiple-fiber probe design parameters produce significant changes in the relative sensitivity to sample layers in a manner that agrees with prior computational studies.

© 2003 Optical Society of America

OCIS Codes
(060.2370) Fiber optics and optical communications : Fiber optics sensors
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence

Citation
T. Joshua Pfefer, L. Stephanie Matchette, Amanda M. Ross, and Marwood N. Ediger, "Selective detection of fluorophore layers in turbid media: the role of fiber-optic probe design," Opt. Lett. 28, 120-122 (2003)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-28-2-120

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