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Optics Letters

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  • Vol. 28, Iss. 21 — Nov. 1, 2003
  • pp: 2064–2066

High-resolution optical coherence microscopy for high-speed, in vivo cellular imaging

A. D. Aguirre, P. Hsiung, T. H. Ko, I. Hartl, and J. G. Fujimoto  »View Author Affiliations


Optics Letters, Vol. 28, Issue 21, pp. 2064-2066 (2003)
http://dx.doi.org/10.1364/OL.28.002064


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Abstract

Optical coherence microscopy (OCM) is demonstrated with a high-speed, broadband, reflective-grating phase modulator and a femtosecond Ti:Al2O3 laser. The novel system design permits high-resolution OCM imaging in a new operating regime in which a short coherence gate is used to relax the requirement for high-numerical-aperture confocal axial sectioning. In vivo cellular imaging is demonstrated in the Xenopus laevis tadpole and in human skin with a 3-μm coherence gate and a 30-μm confocal gate. The ability to achieve cellular imaging with a lower numerical aperture should facilitate the development of miniaturized probes for in vivo imaging applications.

© 2003 Optical Society of America

OCIS Codes
(170.0180) Medical optics and biotechnology : Microscopy
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(180.1790) Microscopy : Confocal microscopy
(320.7160) Ultrafast optics : Ultrafast technology

Citation
A. D. Aguirre, P. Hsiung, T. H. Ko, I. Hartl, and J. G. Fujimoto, "High-resolution optical coherence microscopy for high-speed, in vivo cellular imaging," Opt. Lett. 28, 2064-2066 (2003)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-28-21-2064


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