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Optics Letters

Optics Letters


  • Vol. 28, Iss. 21 — Nov. 1, 2003
  • pp: 2064–2066

High-resolution optical coherence microscopy for high-speed, in vivo cellular imaging

A. D. Aguirre, P. Hsiung, T. H. Ko, I. Hartl, and J. G. Fujimoto  »View Author Affiliations

Optics Letters, Vol. 28, Issue 21, pp. 2064-2066 (2003)

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Optical coherence microscopy (OCM) is demonstrated with a high-speed, broadband, reflective-grating phase modulator and a femtosecond Ti:Al2O3 laser. The novel system design permits high-resolution OCM imaging in a new operating regime in which a short coherence gate is used to relax the requirement for high-numerical-aperture confocal axial sectioning. In vivo cellular imaging is demonstrated in the Xenopus laevis tadpole and in human skin with a 3-μm coherence gate and a 30-μm confocal gate. The ability to achieve cellular imaging with a lower numerical aperture should facilitate the development of miniaturized probes for in vivo imaging applications.

© 2003 Optical Society of America

OCIS Codes
(170.0180) Medical optics and biotechnology : Microscopy
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(180.1790) Microscopy : Confocal microscopy
(320.7160) Ultrafast optics : Ultrafast technology

A. D. Aguirre, P. Hsiung, T. H. Ko, I. Hartl, and J. G. Fujimoto, "High-resolution optical coherence microscopy for high-speed, in vivo cellular imaging," Opt. Lett. 28, 2064-2066 (2003)

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  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
  2. M. Rajadhyaksha, M. Grossman, D. Esterowitz, R. H. Webb, and R. R. Anderson, J. Invest. Dermatol. 104, 946 (1995).
  3. J. A. Izatt, M. R. Hee, G. M. Owen, E. A. Swanson, and J. G. Fujimoto, Opt. Lett. 19, 590 (1994).
  4. M. Kempe, W. Rudolph, and E. Welsch, J. Opt. Soc. Am. A 13, 46 (1996).
  5. J. A. Izatt, M. D. Kulkarni, W. Hsing-Wen, K. Kobayashi, and M. V. Sivak, Jr., IEEE J. Sel. Top. Quantum Electron. 2, 1017 (1996).
  6. V. Westphal, H. W. Wang, and J. A. Izatt, in Conference on Lasers and Electro-Optics (CLEO), Vol. 56 of OSA Trends in Optics and Photonics Series (Optical Society of America, Washington, D.C., 2001), pp. 331–332.
  7. W. Drexler, U. Morgner, F. X. Kärtner, C. Pitris, S. A. Boppart, X. D. Li, E. P. Ippen, and J. G. Fujimoto, Opt. Lett. 24, 1221 (1999).
  8. G. J. Tearney, B. E. Bouma, and J. G. Fujimoto, Opt. Lett. 22, 1811 (1997).
  9. A. V. Zvyagin and D. D. Sampson, Opt. Lett. 26, 187 (2001).
  10. B. E. Lemoff and C. P. J. Barty, Opt. Lett. 18, 1651 (1993).
  11. U. Morgner, F. X. Kärtner, S. H. Cho, Y. Chen, H. A. Haus, J. G. Fujimoto, E. P. Ippen, V. Scheuer, G. Angelow, and T. Tschudi, Opt. Lett. 24, 411 (1999).
  12. M. Rajadhyaksha, R. R. Anderson, R. H. Webb, Appl. Opt. 38, 2105 (1999).

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