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Optics Letters

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  • Vol. 28, Iss. 21 — Nov. 1, 2003
  • pp: 2076–2078

Enhanced sensitivity and spatial resolution for in vivo imaging with low-level light-emitting probes by use of biocompatible chemical agents

Yonghong He, Ruikang K. Wang, and Da Xing  »View Author Affiliations


Optics Letters, Vol. 28, Issue 21, pp. 2076-2078 (2003)
http://dx.doi.org/10.1364/OL.28.002076


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Abstract

We describe a technique that uses biocompatible chemical agents to enhance both the sensitivity and the resolution of in vivo imaging with low-level light-emitting probes. We demonstrate experimentally, with chemiluminescence (CL) imaging in vitro as an example, that the detected intensity of CL from treated 3-mm-thick skin tissue is approximately fivefold stronger than that from untreated skin. The spatial resolution correspondingly increases approximately threefold.

© 2003 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence

Citation
Yonghong He, Ruikang K. Wang, and Da Xing, "Enhanced sensitivity and spatial resolution for in vivo imaging with low-level light-emitting probes by use of biocompatible chemical agents," Opt. Lett. 28, 2076-2078 (2003)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-28-21-2076


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