Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Shift of whispering-gallery modes in microspheres by protein adsorption

Not Accessible

Your library or personal account may give you access

Abstract

Biosensors based on the shift of whispering-gallery modes in microspheres accompanying protein adsorption are described by use of a perturbation theory. For random spatial adsorption, theory predicts that the shift should be inversely proportional to microsphere radius R and proportional to protein surface density and excess polarizability. Measurements are found to be consistent with the theory, and the correspondence enables the average surface area occupied by a single protein to be estimated. These results are consistent with crystallographic data for bovine serum albumin. The theoretical shift for adsorption of a single protein is found to be extremely sensitive to the target region, with adsorption in the most sensitive region varying as 1/R5/2. Specific parameters for single protein or virus particle detection are predicted.

© 2003 Optical Society of America

Full Article  |  PDF Article
More Like This
Perturbation approach to resonance shifts of whispering-gallery modes in a dielectric microsphere as a probe of a surrounding medium

Iwao Teraoka, Stephen Arnold, and Frank Vollmer
J. Opt. Soc. Am. B 20(9) 1937-1946 (2003)

Nanolayer characterization through wavelength multiplexing of a microsphere resonator

Mayumi Noto, Frank Vollmer, David Keng, Iwao Teraoka, and Stephen Arnold
Opt. Lett. 30(5) 510-512 (2005)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (2)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Equations (5)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved