OSA's Digital Library

Optics Letters

Optics Letters


  • Vol. 28, Iss. 5 — Mar. 1, 2003
  • pp: 337–339

Imaging tumor angiogenesis by use of combined near-infrared diffusive light and ultrasound

Quing Zhu, NanGuang Chen, and Scott H. Kurtzman  »View Author Affiliations

Optics Letters, Vol. 28, Issue 5, pp. 337-339 (2003)

View Full Text Article

Acrobat PDF (360 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



A novel two-step reconstruction scheme using a combined near-infrared and ultrasound technique and its utility in imaging distributions of optical absorption and hemoglobin concentration of breast lesions are demonstrated. In the first-step image reconstruction, the entire tissue volume is segmented based on initial coregistered ultrasound measurements into lesion and background regions. Reconstruction is performed by use of a finer grid for lesion region and a coarse grid for the background tissue. As a result, the total number of voxels with unknown absorption can be maintained on the same order of total measurements, and the matrix with unknown total absorption distribution is appropriately scaled for inversion. In the second step, image reconstruction is refined by optimization of lesion parameters measured from ultrasound images. It is shown that detailed distributions of wavelength-dependent absorption and hemoglobin concentration of breast carcinoma can be obtained with the new reconstruction scheme.

© 2003 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3830) Medical optics and biotechnology : Mammography
(170.5270) Medical optics and biotechnology : Photon density waves
(170.7170) Medical optics and biotechnology : Ultrasound

Quing Zhu, NanGuang Chen, and Scott H. Kurtzman, "Imaging tumor angiogenesis by use of combined near-infrared diffusive light and ultrasound," Opt. Lett. 28, 337-339 (2003)

Sort:  Author  |  Year  |  Journal  |  Reset


  1. B. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, Neoplasia 2, 26 (2000).
  2. B. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. Osterberg, and K. D. Paulsen, Radiology 218, 261 (2001).
  3. Q. Zhu, T. Durduran, M. Holboke, V. Ntziachristos, and A. Yodh, Opt. Lett. 24, 1050 (1999).
  4. N. G. Chen, P. Y. Guo, S. K. Yan, D. Q. Piao, and Q. Zhu, Appl. Opt. 40, 6367 (2001).
  5. P. Vaupel, F. Kallinowski, and P. Okunieff, Cancer Res. 49, 6449 (1989).

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited