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Optics Letters

Optics Letters


  • Vol. 28, Iss. 5 — Mar. 1, 2003
  • pp: 340–342

Molecular contrast in optical coherence tomography by use of a pump probe technique

K. Divakar Rao, Michael A. Choma, Siavash Yazdanfar, Andrew M. Rollins, and Joseph A. Izatt  »View Author Affiliations

Optics Letters, Vol. 28, Issue 5, pp. 340-342 (2003)

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We describe a novel technique for contrast enhancement in optical coherence tomography (OCT) that makes possible molecular-specific imaging for what is believed to be the first time. A pump–probe technique is employed in which a pulsed pump laser is tuned to ground-state absorption in a molecule of interest. The location of the target molecule population is derived from the resulting transient absorption of OCT sample-arm light acting as probe light. A signal processing technique for three-dimensional localization of the transient absorption signal is described, and preliminary results exhibiting OCT contrast from methylene blue dye in multilayer and scattering phantoms are presented.

© 2003 Optical Society of America

OCIS Codes
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(190.0190) Nonlinear optics : Nonlinear optics

K. Divakar Rao, Michael A. Choma, Siavash Yazdanfar, Andrew M. Rollins, and Joseph A. Izatt, "Molecular contrast in optical coherence tomography by use of a pump probe technique," Opt. Lett. 28, 340-342 (2003)

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