We demonstrate the capability of differential path-length spectroscopy (DPS) to determine the local optical properties of tissue <i>in vivo</i>. DPS measurements on bronchial mucosa are analyzed and yield information on the local blood oxygenation, blood content, average microvessel diameter, and wavelength dependence of the reduced scattering coefficient. Our data collected to date show that cancerous bronchial mucosa has a lower capillary oxygenation and a larger average capillary diameter than normal bronchial mucosa.
© 2004 Optical Society of America
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.7050) Medical optics and biotechnology : Turbid media
Arjen Amelink, Henricus J. C. M. Sterenborg, Martin P. L. Bard, and Sjaak A. Burgers, "In vivo measurement of the local optical properties of tissue by use of differential path-length spectroscopy," Opt. Lett. 29, 1087-1089 (2004)