A recently developed analytical optical coherence tomography (OCT) model [Thrane et al., J. Opt. Soc. Am. A 17, 484 (2000)] allows the extraction of optical scattering parameters from OCT images, thereby permitting attenuation compensation in those images. By expanding this theoretical model, we have developed a new method for extracting optical scattering parameters from multilayered tissue structures <i>in vivo</i>. To verify this, we used a Monte Carlo (MC) OCT model as a numerical phantom to simulate the OCT signal for heterogeneous multilayered tissue. Excellent agreement between the extracted values of the optical scattering properties of the different layers and the corresponding input reference values of the MC simulation was obtained, which demonstrates the feasibility of the method for <i>in vivo</i> applications. This is to our knowledge the first time such verification has been obtained, and the results hold promise for expanding the functional imaging capabilities of OCT.
© 2004 Optical Society of America
(000.4430) General : Numerical approximation and analysis
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(290.4210) Scattering : Multiple scattering
Lars Thrane, Michael H. Frosz, Thomas M. Jørgensen, Andreas Tycho, Harold T. Yura, and Peter E. Andersen, "Extraction of optical scattering parameters and attenuation compensation in optical coherence tomography images of multilayered tissue structures," Opt. Lett. 29, 1641-1643 (2004)