OSA's Digital Library

Optics Letters

Optics Letters


  • Vol. 29, Iss. 17 — Sep. 1, 2004
  • pp: 2010–2012

Fluorescence polarization imaging for delineating nonmelanoma skin cancers

A. N. Yaroslavsky, V. Neel, and R. R. Anderson  »View Author Affiliations

Optics Letters, Vol. 29, Issue 17, pp. 2010-2012 (2004)

View Full Text Article

Acrobat PDF (3153 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



We present a method for detecting nonmelanoma skin cancers using exogenous fluorescence polarization. We built an automated system that permits exogenous fluorescence polarization imaging. It includes a tunable linearly polarized monochromatic light source and a CCD camera equipped with a rotating linear polarizer and a filter to reject excitation light. Two fluorophores that are retained in tumors, toluidine blue and methylene blue, are employed. We demonstrate that fluorescence polarization imaging can be used for accurate delineation of nonmelanoma cancers. The results suggest that this optical technique may be suitable for real-time noninvasive demarcation of epithelial cancers.

© 2004 Optical Society of America

OCIS Codes
(170.1870) Medical optics and biotechnology : Dermatology
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4730) Medical optics and biotechnology : Optical pathology
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle

A. N. Yaroslavsky, V. Neel, and R. R. Anderson, "Fluorescence polarization imaging for delineating nonmelanoma skin cancers," Opt. Lett. 29, 2010-2012 (2004)

Sort:  Author  |  Year  |  Journal  |  Reset


  1. M. Rajadhyaksha, G. Menaker, P. J. Dwyer, T. J. Flotte, and S. González, J. Invest. Dermatol. 117, 1137 (2001).
  2. S. L. Jacques, J. R. Roman, and K. Lee, Lasers Surg. Med. 26, 119 (2000).
  3. A. N. Yaroslavsky, V. Neel, and R. R. Anderson, J. Invest. Dermatol. 121, 259 (2003).
  4. L. Brancaleon, A. J. Durkin, J. H. Tu, G. Menaker, J. D. Fallon, and N. Kollias, Photochem. Photobiol. 73, 178 (2001).
  5. S. Andersson-Engels, G. Canti, R. Cubeddu, C. Eker, C. af Klinteberg, A. Pifferi, K. Svanberg, S. Svanberg, P. Taroni, G. Valentini, and I. Wang, Lasers Surg. Med. 26, 76 (2000).
  6. A. M. Wennberg, F. Gudmundson, B. Stenquist, A. Ternesten, L. Moelne, A. Rosen, and O. Larko, Acta Derm. Venereol. 79, 54 (1999).
  7. D. B. Tata, M. Foresti, J. Cordero, P. Tomashefsky, M. A. Alfano, and R. R. Alfano, Biophys. J. 50, 463 (1986).
  8. A. R. Oseroff, D. Ohuoha, G. Ara, D. McAuliffe, J. Foley, and L. Cincotta, Proc. Natl. Acad. Sci. U.S.A. 83, 9729 (1986).
  9. W. B. Gill, J. L. Huffman, E. S. Lyon, D. H. Bagley, H. W. Schoenberg, and F. H. Straus II, Cancer 53, 2724 (1984).
  10. K. G. Gross, H. K. Steinman, and R. P. Rapini, eds., Mohs Surgery: Fundamentals and Techniques (Mosby, St. Louis, Mo., 1999).
  11. J. R. Lakowic, Principles of Fluorescence Spectroscopy (Plenum, New York, 1983).
  12. M. N. Usacheva, M. C. Teichert, and M. A. Biel, Lasers Surg. Med. 33, 313 (2003).

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited