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Optics Letters

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  • Vol. 29, Iss. 17 — Sep. 1, 2004
  • pp: 2016–2018

Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent

Changhuei Yang, Laura E. L. McGuckin, John D. Simon, Michael A. Choma, Brian E. Applegate, and Joseph A. Izatt  »View Author Affiliations


Optics Letters, Vol. 29, Issue 17, pp. 2016-2018 (2004)
http://dx.doi.org/10.1364/OL.29.002016


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Abstract

We report a new molecular contrast optical coherence tomography (MCOCT) implementation that profiles the contrast agent distribution in a sample by measuring the agent’s spectral differential absorption. The method, spectra triangulation MCOCT, can effectively suppress contributions from spectrally dependent scatterings from the sample without a priori knowledge of the scattering properties. We demonstrate molecular imaging with this new MCOCT modality by mapping the distribution of indocyanine green, a FDA-approved infrared red dye, within a stage 54 Xenopus laevis.

© 2004 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.3880) Medical optics and biotechnology : Medical and biological imaging

Citation
Changhuei Yang, Laura E. L. McGuckin, John D. Simon, Michael A. Choma, Brian E. Applegate, and Joseph A. Izatt, "Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent," Opt. Lett. 29, 2016-2018 (2004)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-29-17-2016


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