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Optics Letters

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  • Vol. 29, Iss. 17 — Sep. 1, 2004
  • pp: 2028–2030

Noncontact measurement of nerve displacement during action potential with a dual-beam low-coherence interferometer

Christopher Fang-Yen, Mark C. Chu, H. Sebastian Seung, Ramachandra R. Dasari, and Michael S. Feld  »View Author Affiliations


Optics Letters, Vol. 29, Issue 17, pp. 2028-2030 (2004)
http://dx.doi.org/10.1364/OL.29.002028


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Abstract

We have used a novel phase-referenced heterodyne dual-beam low-coherence interferometer to perform what we believe are the first noncontact measurements of surface motion in a nerve bundle during the action potential. Nerve displacements of ~ 5-nm amplitude and ~ 10-ms duration are measured without signal averaging. This interferometer may find general application in measurement of small motion in cells and other weakly scattering samples.

© 2004 Optical Society of America

OCIS Codes
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(170.3880) Medical optics and biotechnology : Medical and biological imaging

Citation
Christopher Fang-Yen, Mark C. Chu, H. Sebastian Seung, Ramachandra R. Dasari, and Michael S. Feld, "Noncontact measurement of nerve displacement during action potential with a dual-beam low-coherence interferometer," Opt. Lett. 29, 2028-2030 (2004)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-29-17-2028


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References

  1. K. Iwasa, I. Tasaki, and R. C. Gibbons, Science 210, 338 (1980).
  2. I. Tasaki, Physiol. Chem. Phys. Med. NMR 20, 251 (1998).
  3. R. Sandlin, L. Lerman, W. Barry, and I. Tasaki, Nature 217, 575 (1968).
  4. D. Kleinfeld and A. LaPorta, in Light Scattering Imaging of Neural Tissue Function, D. M. Rector and J. S. George, eds. (Humana, Totowa, N.J., to be published).
  5. L. E. Drain, The Laser Doppler Technique (Wiley, New York, 1980).
  6. P. K. Rastogi, Digital Speckle Pattern Interferometry and Related Techniques (Wiley, Chichester, U.K., 2001).
  7. K. Otsuka, K. Abe, J. Ko, and T. Lim, Opt. Lett. 27, 1339 (2002).
  8. C. Yang, A. Wax, M. S. Hahn, K. Badizadegan, R. R. Dasari, and M. S. Feld, Opt. Lett. 26, 1271 (2001).
  9. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
  10. A. Watanabe, J. Physiol. 389, 223 (1987).
  11. P. Zhang, A. M. Keleshian, and F. Sachs, Nature 413, 428 (2001).

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