We have used a novel phase-referenced heterodyne dual-beam low-coherence interferometer to perform what we believe are the first noncontact measurements of surface motion in a nerve bundle during the action potential. Nerve displacements of ~ 5-nm amplitude and ~ 10-ms duration are measured without signal averaging. This interferometer may find general application in measurement of small motion in cells and other weakly scattering samples.
© 2004 Optical Society of America
Christopher Fang-Yen, Mark C. Chu, H. Sebastian Seung, Ramachandra R. Dasari, and Michael S. Feld, "Noncontact measurement of nerve displacement during action potential with a dual-beam low-coherence interferometer," Opt. Lett. 29, 2028-2030 (2004)