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Optics Letters

Optics Letters

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  • Vol. 29, Iss. 17 — Sep. 1, 2004
  • pp: 2028–2030

Noncontact measurement of nerve displacement during action potential with a dual-beam low-coherence interferometer

Christopher Fang-Yen, Mark C. Chu, H. Sebastian Seung, Ramachandra R. Dasari, and Michael S. Feld  »View Author Affiliations


Optics Letters, Vol. 29, Issue 17, pp. 2028-2030 (2004)
http://dx.doi.org/10.1364/OL.29.002028


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Abstract

We have used a novel phase-referenced heterodyne dual-beam low-coherence interferometer to perform what we believe are the first noncontact measurements of surface motion in a nerve bundle during the action potential. Nerve displacements of ~ 5-nm amplitude and ~ 10-ms duration are measured without signal averaging. This interferometer may find general application in measurement of small motion in cells and other weakly scattering samples.

© 2004 Optical Society of America

OCIS Codes
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(170.3880) Medical optics and biotechnology : Medical and biological imaging

Citation
Christopher Fang-Yen, Mark C. Chu, H. Sebastian Seung, Ramachandra R. Dasari, and Michael S. Feld, "Noncontact measurement of nerve displacement during action potential with a dual-beam low-coherence interferometer," Opt. Lett. 29, 2028-2030 (2004)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-29-17-2028

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