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Optics Letters

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  • Vol. 29, Iss. 17 — Sep. 1, 2004
  • pp: 2034–2036

Experimental proof of the feasibility of using an angled fiber-optic probe for depth-sensitive fluorescence spectroscopy of turbid media

Quan Liu and Nirmala Ramanujam  »View Author Affiliations


Optics Letters, Vol. 29, Issue 17, pp. 2034-2036 (2004)
http://dx.doi.org/10.1364/OL.29.002034


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Abstract

An angled fiber-optic probe that facilitates depth-sensitive fluorescence measurements was developed for enhancing detection of epithelial precancers. The probe was tested on solid, two-layered phantoms and proved to be effective in selectively detecting fluorescence from different layers. Specifically, a larger illumination angle provides greater sensitivity to fluorescence from the top layer as well as yielding an overall higher fluorescence signal. Monte Carlo simulations of a theoretical model of the phantoms demonstrate that increasing the illumination angle results in an increased excitation photon density and, thus, in increased fluorescence generated in the top layer.

© 2004 Optical Society of America

OCIS Codes
(060.2350) Fiber optics and optical communications : Fiber optics imaging
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(300.2530) Spectroscopy : Fluorescence, laser-induced
(300.6540) Spectroscopy : Spectroscopy, ultraviolet

Citation
Quan Liu and Nirmala Ramanujam, "Experimental proof of the feasibility of using an angled fiber-optic probe for depth-sensitive fluorescence spectroscopy of turbid media," Opt. Lett. 29, 2034-2036 (2004)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-29-17-2034


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References

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