We describe a novel imaging technique, second-harmonic-generation optical coherence tomography (SHOCT). This technique combines the spatial resolution and depth penetration of optical coherence tomography (OCT) with the molecular sensitivity of second-harmonic-generation spectroscopy. As a consequence of the coherent detection required for OCT, polarization-resolved images arise naturally. We demonstrate this new technique on a skin sample from the belly of Icelandic salmon, acquiring polarization-resolved SHOCT and OCT images simultaneously.
© 2004 Optical Society of America
Brian E. Applegate, Changhuei Yang, Andrew M. Rollins, and Joseph A. Izatt, "Polarization-resolved second-harmonic-generation optical coherence tomography in collagen," Opt. Lett. 29, 2252-2254 (2004)