OSA's Digital Library

Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Vol. 29, Iss. 20 — Oct. 15, 2004
  • pp: 2378–2380

Highly sensitive differential phase-sensitive surface plasmon resonance biosensor based on the Mach–Zehnder configuration

S. Y. Wu, H. P. Ho, W. C. Law, Chinlon Lin, and S. K. Kong  »View Author Affiliations


Optics Letters, Vol. 29, Issue 20, pp. 2378-2380 (2004)
http://dx.doi.org/10.1364/OL.29.002378


View Full Text Article

Acrobat PDF (382 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

A high-sensitivity surface plasmon resonance (SPR) biosensor based on the Mach–Zehnder interferometer design is presented. The novel feature of the new design is the use of a Wollaston prism through which the phase quantities of the p and s polarizations are interrogated simultaneously. Since SPR affects only the p polarization, the signal due to the s polarization can be used as the reference. Consequently, the differential phase between the two polarizations allows us to eliminate all common-path phase noise while keeping the phase change caused by the SPR effect. Experimental results obtained from glycerin–water mixtures indicate that the sensitivity limit of our scheme is 5.5 × 10-8 refractive-index units per 0.01° phase change. To our knowledge, this is a significant improvement over previously obtained results when gold was used as the sensor surface. Such an improvement in the sensitivity limit should allow SPR biosensors to become a possible replacement for conventional biosensing techniques based on fluorescence. Monitoring of the bovine serum albumin (BSA) binding reaction with BSA antibodies is also demonstrated.

© 2004 Optical Society of America

OCIS Codes
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(170.3890) Medical optics and biotechnology : Medical optics instrumentation

Citation
S. Y. Wu, H. P. Ho, W. C. Law, Chinlon Lin, and S. K. Kong, "Highly sensitive differential phase-sensitive surface plasmon resonance biosensor based on the Mach–Zehnder configuration," Opt. Lett. 29, 2378-2380 (2004)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-29-20-2378

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited