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Optics Letters

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  • Vol. 29, Iss. 6 — Mar. 15, 2004
  • pp: 581–583

Label-free detection of microarrays of biomolecules by oblique-incidence reflectivity difference microscopy

J. P. Landry, X. D. Zhu, and J. P. Gregg  »View Author Affiliations


Optics Letters, Vol. 29, Issue 6, pp. 581-583 (2004)
http://dx.doi.org/10.1364/OL.29.000581


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Abstract

We developed an oblique-incidence reflectivity difference (OI-RD) scanning microscope for label-free imaging of microarrays of biomolecules upon solid substrates. We demonstrate that hybridization reactions in an oligonucleotide microarray fabricated upon a glass slide can be detected by such an OI-RD microscope.

© 2004 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(180.0180) Microscopy : Microscopy
(240.0240) Optics at surfaces : Optics at surfaces
(310.0310) Thin films : Thin films

Citation
J. P. Landry, X. D. Zhu, and J. P. Gregg, "Label-free detection of microarrays of biomolecules by oblique-incidence reflectivity difference microscopy," Opt. Lett. 29, 581-583 (2004)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-29-6-581


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