We developed an oblique-incidence reflectivity difference (OI-RD) scanning microscope for label-free imaging of microarrays of biomolecules upon solid substrates. We demonstrate that hybridization reactions in an oligonucleotide microarray fabricated upon a glass slide can be detected by such an OI-RD microscope.
© 2004 Optical Society of America
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(180.0180) Microscopy : Microscopy
(240.0240) Optics at surfaces : Optics at surfaces
(310.0310) Thin films : Thin films
J. P. Landry, X. D. Zhu, and J. P. Gregg, "Label-free detection of microarrays of biomolecules by oblique-incidence reflectivity difference microscopy," Opt. Lett. 29, 581-583 (2004)