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Optics Letters

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  • Vol. 29, Iss. 9 — May. 1, 2004
  • pp: 959–961

Radiance-based monitoring of the extent of tissue coagulation during laser interstitial thermal therapy

Lee C.-L. Chin, Brian C. Wilson, William M. Whelan, and I. Alex Vitkin  »View Author Affiliations


Optics Letters, Vol. 29, Issue 9, pp. 959-961 (2004)
http://dx.doi.org/10.1364/OL.29.000959


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Abstract

Optical monitoring relates the dynamic changes in measured light intensity to the extent of treatment-induced coagulation that occurs during laser interstitial thermal therapy. We utilized a two-region Monte Carlo simulation to elucidate the nature of the changes in interstitial radiance and fluence that result from the formation of a volume of thermal coagulation surrounding a cylindrical emitter. Using simulation results, we demonstrate that radiance sensors are more sensitive than traditional fluence sensors to coagulation-induced scattering changes. Radiance measurements take advantage of directional detection angles that are more receptive to the onset and passing of the coagulation boundary. We performed experiments with albumen phantoms to demonstrate the practicality of the radiance method for monitoring interstitial laser thermal therapy.

© 2004 Optical Society of America

OCIS Codes
(000.3860) General : Mathematical methods in physics

Citation
Lee C.-L. Chin, Brian C. Wilson, William M. Whelan, and I. Alex Vitkin, "Radiance-based monitoring of the extent of tissue coagulation during laser interstitial thermal therapy," Opt. Lett. 29, 959-961 (2004)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-29-9-959


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