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Optics Letters

Optics Letters


  • Vol. 30, Iss. 12 — Jun. 15, 2005
  • pp: 1488–1490

Common-path phase-shift interferometry surface plasmon resonance imaging system

Y.-D. Su, S.-J. Chen, and T.-L. Yeh  »View Author Affiliations

Optics Letters, Vol. 30, Issue 12, pp. 1488-1490 (2005)

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Surface plasmon resonance (SPR) and common-path phase-shift interferometry (PSI) techniques are integrated in a biosensing imaging system for measuring the two-dimensional spatial phase variation caused by biomolecular interactions on a sensing chip without the need for additional labeling. The common-path PSI technique has the advantage of long-term stability, even when it is subjected to external disturbances. Hence the system meets the requirements of the real-time kinetic studies involved in biomolecular interaction analysis. The proposed SPR-PSI imaging system demonstrates a detection limit of a 2×10^-7 refractive-index change, a long-term phase stability of 2.5×10^-4 pi rms for 4 h, and a spatial phase resolution of 10^-3 pi with a lateral resolution of 100 µm.

© 2005 Optical Society of America

OCIS Codes
(230.5440) Optical devices : Polarization-selective devices
(240.6680) Optics at surfaces : Surface plasmons
(310.6860) Thin films : Thin films, optical properties

Y.-D. Su, S.-J. Chen, and T.-L. Yeh, "Common-path phase-shift interferometry surface plasmon resonance imaging system," Opt. Lett. 30, 1488-1490 (2005)

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