The optoacoustic technique is noninvasive, has high spatial resolution, and potentially can be used to measure the total hemoglobin concentration ([THb]) continuously and accurately. We performed in vitro measurements in blood and in vivo tests in healthy volunteers. Our clinical protocol included rapid infusion of intravenous saline to simulate rapid change in the [THb] during fluid therapy or surgery. Optoacoustic measurements were made from the wrist area overlying the radial artery for more than 1 h. The amplitude of the optoacoustic signal generated in the radial artery closely followed the [THb] measured directly in concurrently collected blood samples.
© 2005 Optical Society of America
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.1610) Medical optics and biotechnology : Clinical applications
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
Irina Y. Petrova, Rinat O. Esenaliev, Yuriy Y. Petrov, Hans-Peter F. Brecht, Christer H. Svensen, Joel Olsson, Donald J. Deyo, and Donald S. Prough, "Optoacoustic monitoring of blood hemoglobin concentration: a pilot clinical study," Opt. Lett. 30, 1677-1679 (2005)