A simple method is proposed for visualizing the depth distribution of a local blood region in skin tissue by using diffuse reflectance images at two isosbestic wavelengths of hemoglobin, 420 and 585 nm. Monte Carlo simulation of light transport specifies a relation between optical densities and the depth of the region under given concentrations of melanin in the epidermis and blood in the dermis. Phantom and in vivo experiments were performed to show the usefulness of the method.
© 2005 Optical Society of America
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
Izumi Nishidate, Yoshihisa Aizu, and Hiromichi Mishina, "Depth visualization of a local blood region in skin tissue by use of diffuse reflectance images," Opt. Lett. 30, 2128-2130 (2005)