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Optics Letters

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  • Vol. 30, Iss. 16 — Aug. 15, 2005
  • pp: 2131–2133

Spectral-domain optical coherence phase microscopy for quantitative phase-contrast imaging

Chulmin Joo, Taner Akkin, Barry Cense, Boris H. Park, and Johannes F. de Boer  »View Author Affiliations


Optics Letters, Vol. 30, Issue 16, pp. 2131-2133 (2005)
http://dx.doi.org/10.1364/OL.30.002131


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Abstract

We describe a novel microscopy technique for quantitative phase-contrast imaging of a transparent specimen. The technique is based on depth-resolved phase information provided by common path spectral-domain optical coherence tomography and can measure minute phase variations caused by changes in refractive index and thickness inside the specimen. We demonstrate subnanometer level path-length sensitivity and present images obtained on reflection from a known phase object and human epithelial cheek cells.

© 2005 Optical Society of America

OCIS Codes
(110.0180) Imaging systems : Microscopy
(110.4500) Imaging systems : Optical coherence tomography
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(170.1530) Medical optics and biotechnology : Cell analysis
(180.3170) Microscopy : Interference microscopy

Citation
Chulmin Joo, Taner Akkin, Barry Cense, Boris H. Park, and Johannes F. de Boer, "Spectral-domain optical coherence phase microscopy for quantitative phase-contrast imaging," Opt. Lett. 30, 2131-2133 (2005)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-30-16-2131


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