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Optics Letters

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  • Vol. 30, Iss. 17 — Sep. 1, 2005
  • pp: 2272–2274

In vivo brain imaging using a portable 3.9 gram two-photon fluorescence microendoscope

Benjamin A. Flusberg, Juergen C. Jung, Eric D. Cocker, Erik P. Anderson, and Mark J. Schnitzer  »View Author Affiliations


Optics Letters, Vol. 30, Issue 17, pp. 2272-2274 (2005)
http://dx.doi.org/10.1364/OL.30.002272


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Abstract

We introduce a compact two-photon fluorescence microendoscope based on a compound gradient refractive index endoscope probe, a DC micromotor for remote adjustment of the image plane, and a flexible photonic bandgap fiber for near distortion-free delivery of ultrashort excitation pulses. The imaging head has a mass of only 3.9 g and provides micrometer-scale resolution. We used portable two-photon microendoscopy to visualize hippocampal blood vessels in the brains of live mice.

© 2005 Optical Society of America

OCIS Codes
(110.2350) Imaging systems : Fiber optics imaging
(110.2760) Imaging systems : Gradient-index lenses
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.2520) Medical optics and biotechnology : Fluorescence microscopy
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5810) Medical optics and biotechnology : Scanning microscopy

Citation
Benjamin A. Flusberg, Juergen C. Jung, Eric D. Cocker, Erik P. Anderson, and Mark J. Schnitzer, "In vivo brain imaging using a portable 3.9 gram two-photon fluorescence microendoscope," Opt. Lett. 30, 2272-2274 (2005)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-30-17-2272


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References

  1. J. C. Jung and M. J. Schnitzer, Opt. Lett. 28, 902 (2003).
  2. J. C. Jung, A. D. Mehta, E. Aksay, R. Stepnoski, and M. J. Schnitzer, J. Neurophysiol. 92, 3121 (2004).
  3. M. J. Levene, D. A. Dombeck, K. A. Kasischke, R. P. Molloy, and W. W. Webb, J. Neurophysiol. 91, 1908 (2004).
  4. A. D. Mehta, J. C. Jung, B. A. Flusberg, and M. J. Schnitzer, Curr. Opin. Neurobiol. 14, 617 (2004).
  5. D. Bird and M. Gu, Opt. Lett. 28, 1552 (2003).
  6. W. Gobel, J. N. Kerr, A. Nimmerjahn, and F. Helmchen, Opt. Lett. 29, 2521 (2004). [CrossRef]
  7. D. G. Ouzounov, K. D. Moll, M. A. Foster, W. R. Zipfel, W. W. Webb, and A. L. Gaeta, Opt. Lett. 27, 1513 (2002).
  8. F. Helmchen, D. W. Tank, and W. Denk, Appl. Opt. 41, 2930 (2002).
  9. W. Gobel, A. Nimmerjahn, and F. Helmchen, Opt. Lett. 29, 1285 (2004). [CrossRef]
  10. F. Helmchen, M. S. Fee, D. W. Tank, and W. Denk, Neuron 31, 903 (2001).
  11. L. Giniunas, R. Juskaitis, and S. V. Shatalin, Electron. Lett. 27, 724 (1991).
  12. D. L. Dickensheets and G. S. Kino, Proc. SPIE 2184, 39 (1994).
  13. H. K. Kim, M. J. F. Digonnet, G. S. Kino, J. Shin, and S. Fan, Opt. Express 12, 3436 (2004). [CrossRef]
  14. G. P. Agrawal, Nonlinear Fiber Optics, 3rd ed. (Elsevier Science, San Diego, Calif., 2001).
  15. M. Gu and C. J. R. Sheppard, Optik (Stuttgart) 86, 104 (1990).

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