A reconstruction algorithm for multiwavelength diffuse optical tomography is presented, where instead of using data at each wavelength separately or even simultaneously, the difference in data for multiple wavelength pairs is used to reconstruct absolute concentration maps of chromophores. The results indicate a dramatic improvement in image reconstruction and the elimination of image artifacts, which are often associated with unknown measurement errors such as coupling coefficients and external boundary variations, because these errors are often less dependent on wavelength, and are effectively removed from the data set of the first derivative of intensity with respect to wavelength.
© 2005 Optical Society of America
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.6960) Medical optics and biotechnology : Tomography
Medical Optics and Biotechnology
Heng Xu, Brian W. Pogue, Roger Springett, and Hamid Dehghani, "Spectral derivative based image reconstruction provides inherent insensitivity to coupling and geometric errors," Opt. Lett. 30, 2912-2914 (2005)