We describe gold nanocages as a new class of potential contrast agent for spectroscopic optical coherence tomography (OCT). Monodispersed gold nanocages of an ∼35 nm edge length exhibit strong optical resonance, with the peak wavelength tunable in the near-infrared range. We characterized the optical properties of the nanocage by using OCT experiments along with numerical calculations, revealing an absorption cross section approximately 5 orders of magnitude larger than conventional dyes. Experiments with tissue phantoms demonstrated that the nanocages provide enhanced contrast for spectroscopic as well as conventional intensity-based OCT imaging.
© 2005 Optical Society of America
Medical Optics and Biotechnology
Hu Cang, Tao Sun, Zhi-Yuan Li, Jingyi Chen, Benjamin J. Wiley, Younan Xia, and Xingde Li, "Gold nanocages as contrast agents for spectroscopic optical coherence tomography," Opt. Lett. 30, 3048-3050 (2005)