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Optics Letters

Optics Letters


  • Editor: Anthony J. Campillo
  • Vol. 30, Iss. 22 — Nov. 15, 2005
  • pp: 3048–3050

Gold nanocages as contrast agents for spectroscopic optical coherence tomography

Hu Cang, Tao Sun, Zhi-Yuan Li, Jingyi Chen, Benjamin J. Wiley, Younan Xia, and Xingde Li  »View Author Affiliations

Optics Letters, Vol. 30, Issue 22, pp. 3048-3050 (2005)

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We describe gold nanocages as a new class of potential contrast agent for spectroscopic optical coherence tomography (OCT). Monodispersed gold nanocages of an ∼35 nm edge length exhibit strong optical resonance, with the peak wavelength tunable in the near-infrared range. We characterized the optical properties of the nanocage by using OCT experiments along with numerical calculations, revealing an absorption cross section approximately 5 orders of magnitude larger than conventional dyes. Experiments with tissue phantoms demonstrated that the nanocages provide enhanced contrast for spectroscopic as well as conventional intensity-based OCT imaging.

© 2005 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(300.1030) Spectroscopy : Absorption

ToC Category:
Medical Optics and Biotechnology

Hu Cang, Tao Sun, Zhi-Yuan Li, Jingyi Chen, Benjamin J. Wiley, Younan Xia, and Xingde Li, "Gold nanocages as contrast agents for spectroscopic optical coherence tomography," Opt. Lett. 30, 3048-3050 (2005)

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