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Optics Letters

Optics Letters


  • Editor: Anthony J. Campillo
  • Vol. 30, Iss. 23 — Dec. 1, 2005
  • pp: 3189–3191

Subfemtomole detection of small molecules with microsphere sensors

Ian M. White, Niranjan M. Hanumegowda, and Xudong Fan  »View Author Affiliations

Optics Letters, Vol. 30, Issue 23, pp. 3189-3191 (2005)

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We investigated the feasibility of using a silica microsphere sensor for detection of small molecules. Using the silica molecules (60 Da) at the sphere’s surface as a model system, we measured the spectral shifts in the whispering-gallery modes (WGMs) when the sphere size was decreased by a hydrofluoric acid (HF) solution. The results demonstrate that our sensor is capable of detecting a 4 pm (or 0.01 layer of silica) decrease in sphere radius, corresponding to a change of 0.4 fmol silica molecule. These results suggest that small molecules can be detected in trace quantities at the surface of an optical microsphere sensor.

© 2005 Optical Society of America

OCIS Codes
(170.4520) Medical optics and biotechnology : Optical confinement and manipulation
(230.5750) Optical devices : Resonators
(300.6320) Spectroscopy : Spectroscopy, high-resolution

ToC Category:
Optical Devices

Virtual Issues
Vol. 1, Iss. 1 Virtual Journal for Biomedical Optics

Ian M. White, Niranjan M. Hanumegowda, and Xudong Fan, "Subfemtomole detection of small molecules with microsphere sensors," Opt. Lett. 30, 3189-3191 (2005)

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