Subfemtomole detection of small molecules with microsphere sensors
Optics Letters, Vol. 30, Issue 23, pp. 3189-3191 (2005)
http://dx.doi.org/10.1364/OL.30.003189
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Abstract
We investigated the feasibility of using a silica microsphere sensor for detection of small molecules. Using the silica molecules (60 Da) at the sphere's surface as a model system, we measured the spectral shifts in the whispering-gallery modes (WGMs) when the sphere size was decreased by a hydrofluoric acid (HF) solution. The results demonstrate that our sensor is capable of detecting a 4 pm (or 0.01 layer of silica) decrease in sphere radius, corresponding to a change of 0.4 fmol silica molecule. These results suggest that small molecules can be detected in trace quantities at the surface of an optical microsphere sensor.
© 2005 Optical Society of America
OCIS Codes
(170.4520) Medical optics and biotechnology : Optical confinement and manipulation
(230.5750) Optical devices : Resonators
(300.6320) Spectroscopy : Spectroscopy, high-resolution
ToC Category:
Optical Devices
Virtual Issues
Vol. 1, Iss. 1 Virtual Journal for Biomedical Optics
Citation
Ian M. White, Niranjan M. Hanumegowda, and Xudong Fan, "Subfemtomole detection of small molecules with microsphere sensors," Opt. Lett. 30, 3189-3191 (2005)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-30-23-3189
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