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Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Anthony J. Campillo
  • Vol. 30, Iss. 24 — Dec. 15, 2005
  • pp: 3344–3346

Integrated optics ring-resonator sensors for protein detection

A. Ksendzov and Y. Lin  »View Author Affiliations


Optics Letters, Vol. 30, Issue 24, pp. 3344-3346 (2005)
http://dx.doi.org/10.1364/OL.30.003344


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Abstract

Using an integrated optics ring-resonator biosensor, we have demonstrated the detection of protein in low concentrations. We detected 0.3 nM of avidin in a buffered saline solution; the calculated detection limit is 0.1 nM (6.8ng/ml) for avidin, which compares favorably with those of other optical protein detection techniques. Further improvement is possible. Our ring resonator utilizes SixNy/SiO2 waveguides, which, owing to evanescent field interaction, change the effective refractive index when target molecules are immobilized on their surfaces. The selectivity of the sensor depends on the biotin surface coating, which causes the specific binding and immobilization of avidin.

© 2005 Optical Society of America

OCIS Codes
(130.6010) Integrated optics : Sensors
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(230.3120) Optical devices : Integrated optics devices

ToC Category:
Medical Optics and Biotechnology

Virtual Issues
Vol. 1, Iss. 1 Virtual Journal for Biomedical Optics

Citation
A. Ksendzov and Y. Lin, "Integrated optics ring-resonator sensors for protein detection," Opt. Lett. 30, 3344-3346 (2005)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-30-24-3344


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References

  1. M. Henning, Sens. Mater. 14, 339 (2002).
  2. N. T. Greene, S. L. Morgan, and K. D. Shimizu, Chem. Commun. 10, 1172 (2004).
  3. R. Karlsson and R. Stahlberg, Anal. Biochem. 288, 274 (1995).
  4. E. Krioukov, D. J. W. Klunder, A. Driessen, J. Greve, and C. Otto, Opt. Lett. 27, 512 (2002).
  5. F. Vollmer, D. Braun, A. Libchaber, M. Khoshsima, I. Teraoka, and S. Arnold, Appl. Phys. Lett. 80, 4057 (2002). [CrossRef]
  6. K. Tiefenthaler and W. Lucosz, Opt. Lett. 10, 137 (1984).
  7. M. Weisser, G. Tovar, S. Mittler-Neher, W. Knoll, F. Brosinger, H. Freimuth, M. Lacher, and W. Ehrfeld, Biosens. Bioelectron. 14, 405 (1999).
  8. A. Ksendzov, M. L. Homer, and A. M. Manfreda, Electron. Lett. 40, 63 (2004).
  9. R. Polzius, E. Diessel, F. F. Bier, and U. Bilitewski, Anal. Biochem. 248, 269 (1997).
  10. A. Yimit, X. Huang, Y. Xu, T. Ameliya, and K. Itoh, Chem. Lett. 32, 86 (2003).
  11. P. Rabiei, W. H. Steier, C. Zhang, and L. R. Dalton, J. Lightwave Technol. 20, 1968 (2002). [CrossRef]

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