OSA's Digital Library

Optics Letters

Optics Letters


  • Editor: Anthony J. Campillo
  • Vol. 30, Iss. 24 — Dec. 15, 2005
  • pp: 3344–3346

Integrated optics ring-resonator sensors for protein detection

A. Ksendzov and Y. Lin  »View Author Affiliations

Optics Letters, Vol. 30, Issue 24, pp. 3344-3346 (2005)

View Full Text Article

Acrobat PDF (98 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



Using an integrated optics ring-resonator biosensor, we have demonstrated the detection of protein in low concentrations. We detected 0.3 nM of avidin in a buffered saline solution; the calculated detection limit is 0.1 nM (6.8ng/ml) for avidin, which compares favorably with those of other optical protein detection techniques. Further improvement is possible. Our ring resonator utilizes SixNy/SiO2 waveguides, which, owing to evanescent field interaction, change the effective refractive index when target molecules are immobilized on their surfaces. The selectivity of the sensor depends on the biotin surface coating, which causes the specific binding and immobilization of avidin.

© 2005 Optical Society of America

OCIS Codes
(130.6010) Integrated optics : Sensors
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(230.3120) Optical devices : Integrated optics devices

ToC Category:
Medical Optics and Biotechnology

Virtual Issues
Vol. 1, Iss. 1 Virtual Journal for Biomedical Optics

A. Ksendzov and Y. Lin, "Integrated optics ring-resonator sensors for protein detection," Opt. Lett. 30, 3344-3346 (2005)

Sort:  Author  |  Year  |  Journal  |  Reset


  1. M. Henning, Sens. Mater. 14, 339 (2002).
  2. N. T. Greene, S. L. Morgan, and K. D. Shimizu, Chem. Commun. 10, 1172 (2004).
  3. R. Karlsson and R. Stahlberg, Anal. Biochem. 288, 274 (1995).
  4. E. Krioukov, D. J. W. Klunder, A. Driessen, J. Greve, and C. Otto, Opt. Lett. 27, 512 (2002).
  5. F. Vollmer, D. Braun, A. Libchaber, M. Khoshsima, I. Teraoka, and S. Arnold, Appl. Phys. Lett. 80, 4057 (2002). [CrossRef]
  6. K. Tiefenthaler and W. Lucosz, Opt. Lett. 10, 137 (1984).
  7. M. Weisser, G. Tovar, S. Mittler-Neher, W. Knoll, F. Brosinger, H. Freimuth, M. Lacher, and W. Ehrfeld, Biosens. Bioelectron. 14, 405 (1999).
  8. A. Ksendzov, M. L. Homer, and A. M. Manfreda, Electron. Lett. 40, 63 (2004).
  9. R. Polzius, E. Diessel, F. F. Bier, and U. Bilitewski, Anal. Biochem. 248, 269 (1997).
  10. A. Yimit, X. Huang, Y. Xu, T. Ameliya, and K. Itoh, Chem. Lett. 32, 86 (2003).
  11. P. Rabiei, W. H. Steier, C. Zhang, and L. R. Dalton, J. Lightwave Technol. 20, 1968 (2002). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited