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Optics Letters

Optics Letters


  • Editor: Anthony J. Campillo
  • Vol. 30, Iss. 24 — Dec. 15, 2005
  • pp: 3347–3349

Fluorescence-lifetime-based tomography for turbid media

Anand T. Kumar, Jesse Skoch, Brian J. Bacskai, David A. Boas, and Andrew K. Dunn  »View Author Affiliations

Optics Letters, Vol. 30, Issue 24, pp. 3347-3349 (2005)

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We derive a novel algorithm to recover the in vivo distributions of fluorophores based on an asymptotic lifetime analysis of time-domain fluorescence measurements with turbid tissue. We experimentally demonstrate the advantage offered by this method in localizing fluorophores with distinct lifetimes. This algorithm has wide applicability for diagnostic fluorescence imaging in the presence of several-centimeter-thick biological tissue, since fluorescence lifetime is a sensitive indicator of local tissue environment and interactions at the molecular level.

© 2005 Optical Society of America

OCIS Codes
(170.3650) Medical optics and biotechnology : Lifetime-based sensing
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Medical Optics and Biotechnology

Virtual Issues
Vol. 1, Iss. 1 Virtual Journal for Biomedical Optics

Anand T. Kumar, Jesse Skoch, Brian J. Bacskai, David A. Boas, and Andrew K. Dunn, "Fluorescence-lifetime-based tomography for turbid media," Opt. Lett. 30, 3347-3349 (2005)

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