Molecular contrast in optical coherence tomography (OCT) is demonstrated by use of coherent anti-Stokes Raman scattering (CARS) for molecular sensitivity. Femtosecond laser pulses are focused into a sample by use of a low-numerical-aperture lens to generate CARS photons, and the backreflected CARS signal is interferometrically measured. With the chemical selectivity provided by CARS and the advanced imaging capabilities of OCT, this technique may be useful for molecular contrast imaging in biological tissues. CARS can be generated and interferometrically measured over at least 600mm of the depth of field of a low-numerical-aperture objective.
© 2005 Optical Society of America
(040.2840) Detectors : Heterodyne
(110.4500) Imaging systems : Optical coherence tomography
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(190.4410) Nonlinear optics : Nonlinear optics, parametric processes
Jeremy S. Bredfeldt, Claudio Vinegoni, Daniel L. Marks, and Stephen A. Boppart, "Molecularly sensitive optical coherence tomography," Opt. Lett. 30, 495-497 (2005)