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Optics Letters

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  • Vol. 30, Iss. 6 — Mar. 15, 2005
  • pp: 625–627

In vivo dark-field reflection-mode photoacoustic microscopy

Konstantin Maslov, Gheorghe Stoica, and Lihong V. Wang  »View Author Affiliations


Optics Letters, Vol. 30, Issue 6, pp. 625-627 (2005)
http://dx.doi.org/10.1364/OL.30.000625


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Abstract

Reflection-mode photoacoustic microscopy with dark-field laser pulse illumination and high-numerical-aperture ultrasonic detection is designed and implemented in noninvasively imaged blood vessels in the skin in vivo. Dark-field optical illumination minimizes the interference caused by strong photoacoustic signals from superficial structures. A high-numerical-aperture acoustic lens provides high lateral resolution, 45-120 µm in this system. A broadband ultrasonic detection system provides high axial resolution, estimated to be ∼15 µm. The optical illumination and ultrasonic detection are in a coaxial confocal configuration for optimal image quality. The system is capable of imaging optical-absorption contrast as deep as 3 mm in biological tissue.

© 2005 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(180.5810) Microscopy : Scanning microscopy

Citation
Konstantin Maslov, Gheorghe Stoica, and Lihong V. Wang, "In vivo dark-field reflection-mode photoacoustic microscopy," Opt. Lett. 30, 625-627 (2005)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-30-6-625


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